Emeritus Professor of Structural Biochemistry and Emeritus Member of the Centre
Malcolm Walkinshaw’s interest is in mechanisms of molecular recognition and in the regulation of protein-ligand and protein-DNA interactions. Structural and enzymatic studies of allosteric proteins in the glycolytic pathway have been used to develop biologically active drug-like molecules that are active against trypanosome parasites. Similar approaches have been used to develop small molecule ligands that inhibit cyclophilin isoforms and these are currently being investigated for their potential antiviral and anti-cancer activities.
McNae IW, Kinkead J, Malik D, Yen LH, Walker MK, Swain C, et al. Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nat Commun. 2021;12:1052.
Zhong W, Li K, Cai Q, Guo J, Yuan M, Wong YH, et al. Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism. Biochem Biophys Res Commun. 2020;532:370-6.
Pinto Torres JE, Yuan M, Goossens J, Versees W, Caljon G, Michels PA, et al. Structural and kinetic characterization of Trypanosoma congolense pyruvate kinase. Mol Biochem Parasitol. 2020;236:111263