Seminars

Institute of Cell Biology Seminar Series

 

Seminars are held on Mondays at 12.00 noon or Wednesdays in May at 12.00 noon in Lecture Theatre 1, Daniel Rutherford Building

Everyone is welcome to attend.

Semester Two:  January - June 2018

 

Date

Speaker

Host

8 Jan 2018

Susana Godinho

Barts Cancer Institute, Queen Margaret University London

Julie Welburn

15 Jan 2018

Yves Barral

Institute of Biochemistry, ETH Zurich, Switzerland

Bill Earnshaw

22 Jan 2018

Carolyn Moores

Department of Biological Sciences, Birbeck, University of London

Ken Sawin

29 Jan 2018

Michael Blatt

Institute of Molecular Cell and Systems Biology, University of Glasgow

Naomi Nakayama

5 Feb 2018

Jan Löwe

Structural Studies, MRC Laboratory of Molecular Biology, Cambridge

Meriem El Karoui

12 Feb 2018

Buzz Baum

MRC Laboratory of Molecular Cell Biology, UCL

Julie Welburn

19 Feb 2018

NO SEMINAR

 

26 Feb 2018

Etienne Bucher

Institut de Recherche en Horticulture et Semences, Centre Angers-Nantes/INRA-IRHS

Attila Molnar

5 March 2018

Alena Shkumatava

Genetics and Developmental Biology, Institut Curie

Atlanta Cook

12 March 2018

Steve Brusatte

School of Geosciences, University of Edinburgh

Robin Allshire

19 March 2018

Bob Vander Meer

Center for Medical, Agricultural, and Veterinary Entomology, USDA

Janice Bramham

26 March 2018

Kim Hammond-Kosack

Molecular Plant Pathology, Biointeractions and Crop Protection, Rothamsted Research

Gary Loake

2 April 2018

NO SEMINAR - EASTER MONDAY

 

9 April 2018

NO SEMINAR – EASTER HOLIDAYS

 

16 April 2018

tbc

 

23 April 2018

Alessia Buscaino

School of Biosciences, University of Kent

David Finnegan

30 April 2018

tbc

 

Wed 2 May 2018

Peter Askjaer

Centro Andaluz de Biología del Desarrollo, Seville, Spain

Charles Dixon

Eric Schirmer

Wed 9 May 2018

No seminar – ISAB meeting

 

Wed 16 May 2018

Seminar Cancelled

 

Wed 23 May 2018

Michiel Vermeulen

Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands

Elana Bryan

Philipp Voigt

11 June 2018

Laurent Blanchoin

Institute of Life Sciences Research and Technologies, CEA, Grenoble

Andrew Goryachev

18 June 2018

Mark Dodding

School of Biochemistry, University of Bristol

Tony Ly

25 June 2018

Matthias Heinemann

Molecular Systems Biology, University of Groningen

Meriem El Karoui

25 June 2018

Dominic van Essen

Institute for Research on Cancer and Aging, Nice

Patrick Heun (1pm)

Michael Swann Building S7.15

 

Seminar details (including ad hoc seminars)

Date Event
23rd May 2018
12:00
Daniel Rutherford Building
G.27, Lecture Theatre 1

Michiel Vermeulen - Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands

WT PhD Programme Seminar - Deciphering (de)regulation of gene expression in health and disease using integrative omics approaches

The development of an adult human being from a single fertilized egg is accompanied by the generation of ~200 functionally distinct cell types. Each of these cell types expresses only a subset of the 20.000 genes that the human genome encodes for. Cell-type specific gene expression patterns thus ensure the generation of hundreds of phenotypes based on a single genotype. Transcription factors play an important role in driving cell-type specific gene expression, but so-called epigenetic modifications of DNA and core histones also regulate changes in gene expression and phenotype during development and during adult life. Our lab is using state-of-the-art quantitative mass-spectrometry based (interaction) proteomics and next generation DNA sequencing technology to decipher (epi)genetic regulation of gene expression in (differentiated) stem cells. In my lecture I will give an overview of current projects related to this topic.

Host: PhilippVoigt and Elana Bryan


2nd May 2018
12:00
Daniel Rutherford Building
G.27, Lecture Theatre 1

Peter Askjaer - Centro Andaluz de Biología del Desarrollo, Seville

WT PhD Programme Seminar - The function of nuclear pore proteins in nuclear assembly and chromatin organisation

Nuclear pore complexes (NPCs) are fascinating molecular machines. They are essential regulators of nucleocytoplasmic transport, gene expression and genome stability and NPC components, the nucleoporins (NUPs), are involved in kinetochore assembly. The nucleoporin MEL-28/ELYS plays a critical role in NPC assembly through recruitment of the NUP107-160 subcomplex, and is required for correct meiotic and mitotic chromosomes segregation. However, MEL-28 is also expressed in post-mitotic cells, suggesting that it might have additional functions. In support of this, we have observed that inactivation of MEL-28 in post-mitotic cells causes a dramatic lifespan reduction.

 

We have mapped several functional domains in MEL-28, including a C-terminal DNA binding domain. Combined with the observation that a significant fraction of MEL-28 localises in the nucleoplasm, we speculate that MEL-28 might be directly involved in control of gene expression. To identify genes potentially regulated by MEL-28 we performed DamID experiments. This revealed that MEL-28’s binding profile is different from those of others nuclear envelope proteins (NPP-22/NDC1, LMN-1/lamin and EMR-1/emerin), associating more frequently with chromosome centres.


Interestingly, we found a positive correlation between MEL-28 peaks and active transcription markers, such as AMA-1/RNA pol II and methylated histone H3K4 and H3K36. In contrast, LMN-1/lamin and EMR-1/emerin are enriched outside MEL-28 associated domains (MADs). Moreover, expression levels of genes in MADs are higher than in MEL-28 gaps. MADs are enriched for genes involved in general cell biology processes but also larval development and locomotion.
To analyse the functional relevance of MEL-28’s association to chromatin, we are currently studying the effect of MEL-28 depletion on nuclear organization and gene expression. Finally, I will report behavioural data of mel-28 mutants, including developmental progression using a novel luciferase-based high-throughput method.

Host: Eric Schirmer and Charles Dixon


25th Jan 2017
13:00
Michael Swann Building
S7.20

Michael Markie, Wellcome Open Research

Wellcome Open Research: a new publishing initiative from the Wellcome Trust

Wellcome Open Research is a new publishing platform that provides all Wellcome researchers with a place to rapidly publish any results they think are worth sharing.

 

Based on the F1000Research publishing model, Wellcome Open Research will make research outputs available faster and in ways that support reproducibility and transparency. It uses an open access model of immediate publication followed by transparent, invited peer review and inclusion of supporting data. It encourages the publication of all research outputs including data sets, negative results, protocols, case reports, incremental findings as well as more traditional narrative-based articles.

 

This 20 minute presentation by Michael Markie (Publisher, Wellcome Open Research) will discuss the aims and motivations for establishing this platform, how it works and the benefits it offers to researchers. The presentation will then be followed by the opportunity to ask questions and discuss the platform.

Host: Wellcome Trust Centre for Cell Biology