Transcription-coupled changes to chromatin underpin gene silencing by transcriptional interference

Ard, R. and Allshire. R.C.

Nucl. Acids Res. first published online September 8, 2016 doi:10.1093/nar/gkw801


We demonstrate that transcriptional interference of the tgp1+ and pho1+ genes involves transcription-coupled chromatin changes mediated by conserved elongation factors Set2, Clr6CII, Spt6 and FACT that travel with RNAPII. Given that eukaryotic genomes are pervasively transcribed, transcriptional interference likely represents a more general feature of gene regulation than is currently appreciated.

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