Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway

Mutavchiev, D.R., Leda, M., and Sawin, K.E.

Current Biology (2016) DOI: 10.1016/j.cub.2016.08.048

The Rho family GTPase Cdc42 is a key regulator of eukaryotic cellular organization and cell polarity. In this work Mutavchiev uncover a link between stress signaling and Cdc42-dependent cell polarity in fission yeast. They show that dispersal of the Cdc42 polarity module from growth sites after treatment with the actin drug latrunculin A depends on Sty1, a homolog of mammalian p38 MAP kinase. Activation of Sty1 alone is also sufficient for dispersal.

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