A pathway for mitotic chromosome formation

Gibcus, J.H., Samejima, K., Goloborodko, A., Samejima, I., Naumova, N., Nuebler, J., Kanemaki, M.T., Xie, L., Paulson, J.R., Earnshaw,W.C., Mirny,L.A., Dekker, J.

Science 18 Jan 2018: eaao6135 DOI: 10.1126/science.aao6135

In this paper we integrate genetic, genomic and computational approaches to characterize the key steps in mitotic chromosome formation from the G2 nucleus to metaphase, and identify roles of specific molecular machines, condensin I and II, in these major conformational transitions.

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