Oligomerization of Drosophila Nucleoplasmin-like protein is required for its centromere localization

Anselm, E., Thomae, A.W., Arocia Jeyaprakash, A., Heun, P

Nucleic Acids Research (2018) 46, 11274-11286

The Nucleoplasmin Like Protein, NLP and its paralog NPH (brown) form a hetero-pentamer that co-localises with clusters of centromeres in Drosophila. STED superresolution microscopy revealed that NLP (green) and different centromeres (red) form distinct domains with little overlap allowing unprecedented insights into the substructure of centromere clusters.


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