Oleic Acid induces miR-7 processing through remodelling of pri-miR-7/protein complex

Kumar S, Downie Ruiz Velasco A, and Michlewski G.

Journal of Molecular Biology (2017) 429: 1638–1649

Oleic Acid (OA), a monounsaturated Omega-9 fatty acid, augments processing of microRNA-7 primary transcript (pri-miR-7-1) by inhibiting binding of negative regulatory factors (HuR and MSI2) to pri-miR-7-1. Our results show that OA can regulate microRNA biogenesis by remodeling RNA-protein complexes.

doi:10.1016/j.jmb.2017.05.001

Journal Link:

http://www.sciencedirect.com/science/article/pii/S0022283617301997

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