A novel microtubule nucleation pathway for meiotic spindle assembly in oocytes

Romé, P., Ohkura, H.

J Cell Biol. (2018) 217:3431-3445

The paper reports discovery of a novel microtubule nucleation pathway for meiotic spindle assembly in oocytes.  It is active specifically in oocytes but not in mitotic cells, and acts complementarily to the Augmin pathway.  Spatial regulation of this pathway is critical to restrict the spindle assembly to the vicinity of chromosomes in oocytes.

Journal Link:

http://jcb.rupress.org/content/217/10/3431.long

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