Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast

R. Ard, P. Tong, R. C. Allshire

Nat Comms (2014) 5: 5576

 

The presence of long non-coding RNAs (lncRNAs) is pervasive across genomes, yet few lncRNAs have clearly established mechanisms of action. Here the authors demonstrate that the fission yeast lncRNA nc-tgp1 governs drug tolerance via transcriptional interference of a permease gene.

Journal Link:

http://www.nature.com/ncomms/2014/141127/ncomms6576/full/ncomms6576.html

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