Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation

Bobkov, G.O.M., Gilbert, N., Heun, P.

J. Cell Biol (2018) DOI: 10.1083/jcb.201611087

Transcription is important for the loading of the epigenetic centromere mark CENP-A, yet its role remains unclear. In this study, we report that transcription-mediated chromatin remodelling enables the transition of centromeric CENP-A from chromatin association to full nucleosome incorporation.

 

Journal Link:

http://jcb.rupress.org/content/early/2018/04/05/jcb.201611087

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