3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin

Booth, D.G., Beckett, A.J., Molina, O., Samejima, I., Masumoto, H., Kouprina, N., Larionov, V., Prior, I.A., and Earnshaw, W.C.

Mol.Cell. 2016 Nov 17;64(4):790-802. doi 10.1016/j.molcel.2016.10.009

3-dimentional correlative light and electron microscopy reveals that ≥ 33% of mitotic chromosomes is not chromatin, but is instead a peripheral layer that is largely derived from nucleoli. This mysterious layer is very little studied, but experiments suggest that it may have important roles in re-establishing the internal organisation of the interphase nucleus after cell division.

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