14-3-3 regulation of Ncd reveals a new mechanism for targeting proteins to the spindle in oocytes

Beaven, R., Nunes Bastos, R., Spanos, C., Romé, P., Cullen, C.F., Rappsilber, J., Giet, R., Goshima, G. and Ohkura, H.

J Cell Biol. 2017 216(10):3029-3039

14-3-3 interacts with the kinesin-14 Ncd and prevents it from binding microtubules. Aurora B provides a spatial cue that releases Ncd from 14-3-3 around chromosomes, allowing Ncd to selectively bind the spindle microtubules in the large volume of oocytes.

Journal Link:

http://jcb.rupress.org/content/216/10/3029

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